Phase 3 data for PCSK9 inhibitor wows

@article{Sheridan2013Phase3D,
  title={Phase 3 data for PCSK9 inhibitor wows},
  author={Cormac Sheridan},
  journal={Nature Biotechnology},
  year={2013},
  volume={31},
  pages={1057-1058}
}
  • C. Sheridan
  • Published 1 December 2013
  • Biology
  • Nature Biotechnology
Pfizer’s decision to move its proprotein convertase subtilisin kexin 9 (PCSK9) inhibitor bococizumab into phase 3 trials, which it disclosed on October 29, adds further momentum to the emergence of a highly anticipated new class of cardiovascular disease drugs that dramatically lowers levels of low-density lipoprotein cholesterol (LDL-c). A couple of weeks previously, Regeneron, of Tarrytown, New York, and Paris-based Sanofi, who are codeveloping a rival antibody called alirocumab, reported the… 
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Two mutations in the gene PCSK9 (encoding proprotein convertase subtilisin/kexin type 9) that cause ADH are reported, a newly identified human subtilase that is highly expressed in the liver and contributes to cholesterol homeostasis.
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