Phase 2b trial of interferon-free therapy for hepatitis C virus genotype 1.

@article{Kowdley2014Phase2T,
  title={Phase 2b trial of interferon-free therapy for hepatitis C virus genotype 1.},
  author={Kris V. Kowdley and Eric J. Lawitz and Fred P Poordad and Daniel E. Cohen and David R Nelson and Stefan Zeuzem and Gregory T. Everson and Paul Y. Kwo and Graham R. Foster and Mark S Sulkowski and Wangang Xie and Tami J. Pilot-Matias and George Liossis and Lois Larsen and Amit Khatri and Thomas J. Podsadecki and Barry Bernstein},
  journal={The New England journal of medicine},
  year={2014},
  volume={370 3},
  pages={222-32}
}
BACKGROUND An interferon-free combination of the protease inhibitor ABT-450 with ritonavir (ABT-450/r), the nonnucleoside polymerase inhibitor ABT-333, and ribavirin showed efficacy against the hepatitis C virus (HCV) in a pilot study involving patients with HCV genotype 1 infection. The addition of another potent agent, the NS5A inhibitor ABT-267, may improve efficacy, especially in difficult-to-treat patients. This study was designed to evaluate multiple regimens of direct-acting antiviral… CONTINUE READING

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