• Medicine
  • Published in
    The Journal of infectious…
    2007
  • DOI:10.1086/518797

Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-Infected, treatment-experienced patients: AIDS clinical trials group 5211.

@article{Gulick2007Phase2S,
  title={Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-Infected, treatment-experienced patients: AIDS clinical trials group 5211.},
  author={Roy M. Gulick and Zhaohui Su and Charles Flexner and Michael D. Hughes and Paul R. Skolnik and Timothy J. Wilkin and Robert E. Gross and Amy Krambrink and Eoin Coakley and Wayne L Greaves and Andrew Zolopa and Richard Reichman and Catherine Godfrey and Martin Hirsch and Daniel R. Kuritzkes},
  journal={The Journal of infectious diseases},
  year={2007},
  volume={196 2},
  pages={
          304-12
        }
}
BACKGROUND Vicriviroc, an investigational CCR5 inhibitor, demonstrated short-term antiretroviral activity in a phase 1 study. METHODS The present study was a double-blind, randomized phase 2 study of vicriviroc in treatment-experienced, human immunodeficiency virus (HIV)-infected subjects experiencing virologic failure while receiving a ritonavir-containing regimen with an HIV-1 RNA level >or=5000 copies/mL and CCR5-using virus. Vicriviroc at 5, 10, or 15 mg or placebo was added to the… CONTINUE READING

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