Phase 2 study of rituximab-ABVD in classical Hodgkin lymphoma.

@article{Kasamon2012Phase2S,
  title={Phase 2 study of rituximab-ABVD in classical Hodgkin lymphoma.},
  author={Yvette L. Kasamon and Heather Jacene and Christopher D Gocke and L. Swinnen and Douglas E Gladstone and Brandy N. Perkins and Brian K Link and Leslie L Popplewell and Thomas Matthew Habermann and Joseph M. Herman and William Matsui and Richard M. Jones and Richard Frederick Ambinder},
  journal={Blood},
  year={2012},
  volume={119 18},
  pages={4129-32}
}
In classical Hodgkin lymphoma, circulating clonotypic malignant cells express CD20, which potentially explains the observed activity of rituximab. This multicenter phase 2 study investigated the combination of rituximab-ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) for stage II-IV untreated classical Hodgkin lymphoma. A goal was to assess the behavior of circulating clonotypic B cells clinically. Of 49 evaluable patients, 69% had stage IIB-IV disease; 8% had CD20(+) Hodgkin and Reed… CONTINUE READING
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Frontline therapy with brentuximab vedotin combined with ABVD or AVD in patients with newly diagnosed advanced stage Hodgkin lymphoma [abstract

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