Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia.

@article{Schulz2002Phase2S,
  title={Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia.},
  author={Holger K. Schulz and Saskia Karina Klein and Ute Rehwald and Marcel Reiser and Axel Hinke and W Knauf and W K Aulitzky and Manfred Hensel and Michael Herold and Dieter Huhn and Michael J Hallek and Volker Diehl and Andreas Engert},
  journal={Blood},
  year={2002},
  volume={100 9},
  pages={3115-20}
}
This multicenter phase 2 trial investigated safety and efficacy of a new immunochemotherapeutic regimen combining rituximab (R) and fludarabine (F) in patients with fludarabine- and anthracycline-naive chronic lymphocytic leukemia (CLL). The rationale for using R + F includes single-agent efficacy of both drugs, in vitro synergism of R and F, and no apparent overlapping toxicity. Of 31 eligible patients with B-CLL enrolled, 20 were previously untreated and 11 relapsed. Treatment consisted of… CONTINUE READING

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