Phase 1 trial of combined chemotherapy and reirradiation for recurrent unresectable head and neck cancer.

Abstract

BACKGROUND The management of recurrent unresectable head and neck cancer remains a challenging problem. Based on the circadian rhythm concept, we sought to determine the maximum tolerated dose (MTD) of infusional 5-flourouracil (5-FU), hydroxyurea (HU), and reirradiation (RT). METHOD Bolus 5-FU was escalated from 300 mg/m(2)/d to a 10-hour infusion… (More)

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@article{Spencer2003Phase1T, title={Phase 1 trial of combined chemotherapy and reirradiation for recurrent unresectable head and neck cancer.}, author={Sharon A. Spencer and Richard Wheeler and G. Peters and Ruby Meredith and Sam Beenken and Lisle Nabel and Ann Wooten and Seng-jaw Soong and Merle Salter}, journal={Head & neck}, year={2003}, volume={25 2}, pages={118-22} }