Phase 1 dose-ranging study of ezatiostat hydrochloride in combination with lenalidomide in patients with non-deletion (5q) low to intermediate-1 risk myelodysplastic syndrome (MDS)

@inproceedings{Raza2012Phase1D,
  title={Phase 1 dose-ranging study of ezatiostat hydrochloride in combination with lenalidomide in patients with non-deletion (5q) low to intermediate-1 risk myelodysplastic syndrome (MDS)},
  author={Azra Raza and Naomi Galili and Deborah A. Mulford and Scott E. Smith and Gail L. Brown and David P Steensma and Roger M. Lyons and Ralph V. Boccia and Mikkael A. Sekeres and Guillermo Garcia-Manero and Ruben A. Mesa},
  booktitle={Journal of hematology & oncology},
  year={2012}
}
BACKGROUND Ezatiostat, a glutathione S-transferase P1-1 inhibitor, promotes the maturation of hematopoietic progenitors and induces apoptosis in cancer cells. RESULTS Ezatiostat was administered to 19 patients with non-deletion(5q) myelodysplastic syndrome (MDS) at one of two doses (2000 mg or 2500 mg/day) in combination with 10 mg of lenalidomide on days 1-21 of a 28-day cycle. No unexpected toxicities occurred and the incidence and severity of adverse events (AEs) were consistent with that… CONTINUE READING
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Gene Expression Studies May Identify Lower Risk Myelodysplastic Syndrome Patients Likely to Respond to Therapy with Ezatiostat Hydrochloride (TLK199) [abstract

  • N Galili, P Tamayo, +4 authors A Raza
  • Proceedings of the American Society of Hematology…
  • 2011
1 Excerpt

Novel Ezatiostat Analogues Disrupt Binding of GSTP1 to All Three Major MAP Kinases (JNK, ERK and p38) and Exhibit ContextDependent Antitumor Activity [abstract

  • F Ali-Osman, T Okamura, +5 authors R Macsata
  • In Proceedings of the AACR-NCIEORTC International…
  • 2011
1 Excerpt

Induction of apoptosis by TLK199 in human leukemia cells [abstract

  • M Stofega, SC Hsu, J Chew, G Keck JG Brown, A Raza, D Cai
  • In Proceedings of the Annual Meeting of the…
  • 2008
1 Excerpt

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