Phase 1/2 study of everolimus in advanced hepatocellular carcinoma.


BACKGROUND The phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway plays a critical role in the pathogenesis of hepatocellular carcinoma (HCC). We performed a single-arm, phase 1/2 study of everolimus in patients with advanced HCC. METHODS Patients with histologically confirmed measurable advanced HCC, 0-2 prior regimens, and adequate… (More)
DOI: 10.1002/cncr.26165


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