Phase–contrast X–ray computed tomography for observing biological soft tissues

@article{Momose1996PhasecontrastXC,
  title={Phase–contrast X–ray computed tomography for observing biological soft tissues},
  author={Atsushi Momose and Tohoru Takeda and Yuji Itai and Keiichi Hirano},
  journal={Nature Medicine},
  year={1996},
  volume={2},
  pages={473-475}
}
Biological soft tissues are almost transparent to hard X rays and therefore cannot be investigated without enhancement with a contrast medium, such as iodine. On the other hand, phase–contrast X–ray imaging is sensitive to light elements1–8. This is because the X–ray phase shift cross section is almost a thousand times larger than the X–ray absorption cross section for light elements such as hydrogen, carbon, nitrogen and oxygen4,5. Hence, phase–contrast X–ray imaging is a promising technique… Expand
Fine Biomedical Imaging Using X-Ray Phase-Sensitive Technique
X-ray imaging is widely used for non-destructive observations of the inner structures of samples in many fields, such as biological, clinical, and industrial ones. The transparency of X-rays is muchExpand
Vessel Imaging by Interferometric Phase-Contrast X-Ray Technique
TLDR
Phase-contrast x-ray imaging explored clear depiction of the vessels using physiological saline with small doses of x-rays with great potential to reveal the structures inside soft tissues. Expand
X-ray phase contrast imaging of soft tissue specimens
In the presented work, we investigated the potential capabilities of contrast improvement in soft tissue achieved by x-ray phase contrast imaging. The Talbot-Lau interferometer method was implementedExpand
X-ray phase contrast tomography by tracking near field speckle
TLDR
A method for three-dimensional (3D) X-ray phase contrast computed tomography (CT) which gives quantitative volumetric information on the real part of the refractive index is reported which makes the technique an attractive candidate for material imaging such as in-vivo imaging of biological systems containing soft tissue. Expand
Applications of phase-contrast x-ray imaging to medicine using an x-ray interferometer
We are investigating possible medical applications of phase- contrast X-ray imaging using an X-ray interferometer. This paper introduces the strategy of the research project and the present status.Expand
Quantitative multimodal x-ray tomography: absorption, phase, and darkfield contrast
The basic principles of x-ray image formation in radiography have remained essentially unchanged since R¨ontgen first discovered x-rays over a hundred years ago. The conventional approach relies onExpand
Perspective for Medical Applications of Phase-Contrast X-Ray Imaging
Interferometric phase-contrast X-ray imaging is experimentally proved to be sensitive to biological soft-tissue features without the need for staining. Radiographic and tomographic applications ofExpand
Second order x-ray in-line phase-contrast imaging
  • W. Cong, Ge Wang
  • Physics, Engineering
  • Optics & Photonics - Optical Engineering + Applications
  • 2014
X-ray phase imaging is sensitive to structural variation of soft tissue, and offers excellent contrast resolution for characterization of cancerous tissues. Also, the cross-section of x-ray phaseExpand
Phase-contrast X-ray imaging of breast
TLDR
The imaging methods developed at the synchrotron radiation facilities will become available in the clinical environment with the ongoing development of compact radiation sources, which produce intense X-ray beams of sufficient coherence. Expand
Cone-beam x-ray phase-contrast tomography for the observation of single cells in whole organs
X-ray imaging enables the nondestructive investigation of interior structures in otherwise opaque samples. In particular the use of computed tomography (CT) allows for arbitrary virtual slicesExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 14 REFERENCES
Phase-contrast imaging with synchrotron X-rays for detecting cancer lesions.
TLDR
For materials such as biologic specimens with a low atomic number, X-ray phase-contrast imaging better differentiates tissues than does the absorption contrast imaging commonly used in radiology. Expand
Demonstration of phase-contrast X-ray computed tomography using an X-ray interferometer
Abstract Phase-contrast X-ray computed tomography (PCX-CT) using an X-ray interferometer is introduced for observing a density distribution inside an organic material. PCX-CT images are compared withExpand
Contrast effect of blood on phase-contrast X-ray imaging.
TLDR
The large phase shift caused by blood is due to red blood cells, which contain hemoglobin molecules with iron atoms, and it is possible that blood produces a structure in a phase-contrast X-ray image. Expand
Phase-contrast x-ray computed tomography for observing biological specimens and organic materials
A novel three‐dimensional x‐ray imaging method has been developed by combining a phase‐contrast x‐ray imaging technique with x‐ray computed tomography. This phase‐contrast x‐ray computed tomographyExpand
The future of X-ray holography
Abstract X-ray holography is a promising technique for high resolution study of biological, microelectronics and materials science specimens. It offers absorption and phase contrast, it is amenableExpand
Phase-contrast radiographs of nonstained rat cerebellar specimen.
TLDR
High sensitivity of phase-contrast radiography is demonstrated with a rat cerebellar specimen without staining it with a contrast medium and the layer structure of the cerebellum can be observed in the obtained image while there is no clear structure in the corresponding absorption-cont contrast image. Expand
Review lecture: Ten years of X-ray interferometry
  • M. Hart
  • Physics
  • Proceedings of the Royal Society of London. A. Mathematical and Physical Sciences
  • 1975
X-ray interferometers were the first optical instruments which utilized many Bragg reflecting components in monolithic blocks of perfect crystal. They have made important contributions to ourExpand
X‐ray sensing pickup tube
An x‐ray sensing pickup tube free of white defects in the scanning area has been developed, and its characteristics have been evaluated. This pickup tube functions in a wide x‐ray energy range from 7Expand
Digital wavefront measuring interferometer for testing optical surfaces and lenses.
TLDR
The system has been designed to optimize the collection of data to give higher than usual accuracy in measuring the individual elements and final performance of assembled diffraction limited optical systems, and furthermore, the short loop time of a few minutes makes the system an attractive alternative to constraints imposed by test glasses in the optical shop. Expand
Absolute Measurement of the (220) Lattice Plane Spacing in a Silicon Crystal
The (220) lattice plane spacing of an almost perfect crystal of silicon was measured by means of a combined scanning ($\mathrm{LLL}$) x-ray interferometer and a two-beam optical interferometer. FromExpand
...
1
2
...