Pharmokinetics of 2'-deoxycoformycin in normal and L1210 leukemic mice.

  title={Pharmokinetics of 2'-deoxycoformycin in normal and L1210 leukemic mice.},
  author={William R. McConnell and R L Furner and Donald L. Hill},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={7 1},
Following intravenous administration, 2'-deoxycoformycin (0.25 mg/kg) was rapidly distributed to tissues of both normal mice and mice bearing L1210 leukemia cells and readily eliminated, primarily by urinary excretion. Elimination of 2'-deoxycoformycin from plasma was biphasic, and half-lives for the alpha- and beta-phases of 10 and 33 min for normal mice and 7 and 40 min for L1210-bearing animals. The volume of distribution at steady state was approximately 20 ml, suggesting that the drug was… CONTINUE READING