Pharmacotherapy of cluster headache

@article{Evers2010PharmacotherapyOC,
  title={Pharmacotherapy of cluster headache},
  author={Stefan Evers},
  journal={Expert Opinion on Pharmacotherapy},
  year={2010},
  volume={11},
  pages={2121 - 2127}
}
  • S. Evers
  • Published 15 August 2010
  • Medicine, Psychology
  • Expert Opinion on Pharmacotherapy
Importance of the field: Cluster headache belongs to the trigemino-autonomic cephalgias and is one of the most devastating idiopathic pain syndromes. Despite its extreme severity and its prevalence of about 0.1%, little attention has been paid to this painful syndrome by either basic or clinical research. Areas covered in this review: All clinical trials on the acute and prophylactic drug treatment of cluster headache are reviewed, including review articles and book chapters. What the reader… 
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TLDR
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TLDR
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TLDR
Analysis of the pain location data shows phase specific frequencies and distributions of pain location during the three stages of a cluster headache attack to better understand cluster headache and to identify further target structures for local treatments.
Headache in Palliative Care
TLDR
This chapter focuses on the differential diagnosis for refractory headache patients, with particular emphasis on two of the most common and disabling headache disorders, migraine and cluster headache.
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TLDR
This case highlights the importance of performing FLAIR-Gd-enhanced MRI in order to accurately detect VZV neuritis.
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TLDR
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References

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TLDR
Zolmitriptan and sumatriptan are effective in the acute treatment of cluster headaches and may provide a useful treatment option, potentially offering convenience over oxygen therapy and a better safety and tolerability profile than ergotamine.
Management of Cluster Headache
TLDR
The relatively short-lasting attack of pain in one eye with typical associated symptoms should lead the family doctor to suspect cluster headache resulting in a referral to a neurologist or a headache centre with experience in the treatment of cluster headache.
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TLDR
Large series suggest that lamotrigine is the most effective preventive agent, with topiramate and gabapentin also being useful in treatment of SUNCT syndrome, and surgical procedures, although in part promising, require further scientific evaluation.
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TLDR
Overall, divalproex sodium was found to be an effective and generally well-tolerated prophylactic treatment option as monotherapy or in polytherapy for migraine and cluster headache.
Botulinum toxin and the management of chronic headaches
  • S. Evers
  • Medicine, Psychology
    Current opinion in otolaryngology & head and neck surgery
  • 2004
TLDR
The studies available from reference systems and published congress contributions on the prophylactic treatment of idiopathic and cervicogenic headache with botulinum toxin were analyzed with respect to study design, headache diagnosis, and the significance of results.
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TLDR
The time has come to use the evidence for a disorder of circadian rhythm in cluster headache to further the development of chronobiotics in the treatment of this disorder.
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TLDR
Five-milligram and 10-mg doses of zolmitriptan intranasal spray are effective within 30 minutes and well tolerated in the treatment of acute cluster headache.
Limited Efficacy of Methysergide in Cluster Headache. A Clinical Experience
TLDR
There was no significant difference in treatment response between the 3 groups of cluster headache, since 4 out of 16 episodic patients, 5 out of 14 primary chronic patients, and 3 out of 12 secondary chronic patients had good or excellent effect without severe side effects.
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TLDR
Medication-overuse headache is a previously underrecognized and treatable problem associated with cluster headache (CH).
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TLDR
Treatment of patients with cluster headache at symptom onset using inhaled high-flow oxygen compared with placebo was more likely to result in being pain-free at 15 minutes.
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