Pharmacotherapy of cluster headache

@article{Evers2010PharmacotherapyOC,
  title={Pharmacotherapy of cluster headache},
  author={S. Evers},
  journal={Expert Opinion on Pharmacotherapy},
  year={2010},
  volume={11},
  pages={2121 - 2127}
}
  • S. Evers
  • Published 2010
  • Medicine
  • Expert Opinion on Pharmacotherapy
Importance of the field: Cluster headache belongs to the trigemino-autonomic cephalgias and is one of the most devastating idiopathic pain syndromes. Despite its extreme severity and its prevalence of about 0.1%, little attention has been paid to this painful syndrome by either basic or clinical research. Areas covered in this review: All clinical trials on the acute and prophylactic drug treatment of cluster headache are reviewed, including review articles and book chapters. What the reader… Expand
Cluster headache: clinical features and therapeutic options.
TLDR
Pharmacotherapy for the treatment of acute attacks and for attack prophylaxis is effective in most patients, and for the minority who do not gain adequate relief, newer invasive techniques are available in some referral centers. Expand
Genetics of Cluster Headache Takes a Leap
TLDR
2 papers by Harder et al and O’Connor et al demonstrate for the first time robust genetic associations to CH, using a classical case control GWAS design, the first evidence to demonstrate that there are genetic variants that contribute to CH predisposition. Expand
Erenumab for chronic cluster headache: A case report
TLDR
Galcanezumab, a monoclonal antibody against calcitonin gene-related peptide (CGRP), significantly reduced the frequency of episodic cluster headache attacks. Expand
Chronic Cluster Headache Update and East–West Comparisons: Focusing on Clinical Features, Pathophysiology, and Management
TLDR
Noteworthy advances have emerged in neuromodulatory therapies for chronic CH, but treatment with calcitonin gene-related peptide (CGRP) monoclonal antibodies has been unsuccessful and divergence of chronic CH between Eastern and Western populations is shown. Expand
Headache in Palliative Care
TLDR
This chapter focuses on the differential diagnosis for refractory headache patients, with particular emphasis on two of the most common and disabling headache disorders, migraine and cluster headache. Expand
Enhancement of the Trigeminal Nerve by VZV Reactivation
A man in his late 30s who was being treated for anaplastic anemia had severe headache. His intermittent attacks of excruciating unilateral headache lasted for several days, thus indicating a clusterExpand
Role of Nitric Oxide in Cluster Headache
TLDR
The issue of whether similar circumstances apply for CH and also the role of NO in the pathophysiology of CH in a wider perspective are discussed. Expand
Gamma Knife Stereotactic Radiosurgery in the Management of Cluster Headache
TLDR
In the future, a prospective trial that compares a single target of TN to dual targets of both the TN and SPG may provide further understanding of the value of SRS for CH. Expand
Gene polymorphism association studies in cluster headache: A field synopsis and systematic meta‐analyses
A plethora of studies have attempted to identify genetic determinants of disease susceptibility and treatment response of patients with cluster headache (CH), but results are often conflicting, andExpand
Pain localization in cluster headache patients: Onset, peak, and radiation
TLDR
To describe differences in pain locations for onset, peak, and radiation aspects of cluster headache (CH) attacks, a model is constructed that ranks the pain locations according to the intensity of the headache. Expand
...
1
2
...

References

SHOWING 1-10 OF 76 REFERENCES
Triptans for acute cluster headache.
TLDR
Zolmitriptan and sumatriptan are effective in the acute treatment of cluster headaches and may provide a useful treatment option, potentially offering convenience over oxygen therapy and a better safety and tolerability profile than ergotamine. Expand
Management of Cluster Headache
TLDR
The relatively short-lasting attack of pain in one eye with typical associated symptoms should lead the family doctor to suspect cluster headache resulting in a referral to a neurologist or a headache centre with experience in the treatment of cluster headache. Expand
Management of cluster headache.
TLDR
Surgical modalities and newer interventions such as the implantation of stereotactic electrodes may be useful and patients should be encouraged to avoid possible triggers such as smoking or alcohol consumption, especially during the duster period. Expand
EFNS guidelines on the treatment of cluster headache and other trigeminal‐autonomic cephalalgias
TLDR
Large series suggest that lamotrigine is the most effective preventive agent, with topiramate and gabapentin also being useful in treatment of SUNCT syndrome, and surgical procedures, although in part promising, require further scientific evaluation. Expand
Divalproex sodium in the treatment of migraine and cluster headaches
TLDR
Overall, divalproex sodium was found to be an effective and generally well-tolerated prophylactic treatment option as monotherapy or in polytherapy for migraine and cluster headache. Expand
Botulinum toxin and the management of chronic headaches
  • S. Evers
  • Medicine
  • Current opinion in otolaryngology & head and neck surgery
  • 2004
TLDR
The studies available from reference systems and published congress contributions on the prophylactic treatment of idiopathic and cervicogenic headache with botulinum toxin were analyzed with respect to study design, headache diagnosis, and the significance of results. Expand
Update on cluster headache.
TLDR
The time has come to use the evidence for a disorder of circadian rhythm in cluster headache to further the development of chronobiotics in the treatment of this disorder. Expand
Effectiveness of intranasal zolmitriptan in acute cluster headache: a randomized, placebo-controlled, double-blind crossover study.
TLDR
Five-milligram and 10-mg doses of zolmitriptan intranasal spray are effective within 30 minutes and well tolerated in the treatment of acute cluster headache. Expand
Cluster headache: A prospective clinical study with diagnostic implications
TLDR
Patients with cluster headache offer a population of primary headache patients with devastating acute attacks of pain and the syndrome is stereotyped with effective evidence-based treatments that are prescribed in only half of patients having cluster headache. Expand
Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study
TLDR
The delay of 2 months or more between implantation and significant clinical improvement suggests that the procedure acts via slow neuromodulatory processes at the level of upper brain stem or diencephalic centres, and could be safer than deep hypothalamic stimulation. Expand
...
1
2
3
4
5
...