Pharmacotherapy of alcohol dependence: a review of the clinical data.

  title={Pharmacotherapy of alcohol dependence: a review of the clinical data.},
  author={Karl F. Mann},
  journal={CNS drugs},
  volume={18 8},
Over the last 20 years, the role of adjuvant pharmacotherapy in optimising outcome in rehabilitation programmes for alcohol-dependent patients has become increasingly evident. New avenues for rational drug treatment have arisen from better understanding of the neurobiological substrates of alcohol dependence, including adaptive changes in amino acid neurotransmitter systems, stimulation of dopamine and opioid peptide systems, and, possibly, changes in serotonergic activity. Disulfiram… CONTINUE READING
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