Pharmacotherapy for posttraumatic stress disorder: A status report

  title={Pharmacotherapy for posttraumatic stress disorder: A status report},
  author={Matthew J. Friedman},
  journal={Psychiatry and Clinical Neurosciences},
  • M. Friedman
  • Published 1 September 1998
  • Psychology, Biology
  • Psychiatry and Clinical Neurosciences
Pharmacotherapy for posttraumatic stress disorder (PTSD) appears to be a promising approach because many neurobiological systems appear to be altered in PTSD patients. This review encompasses the current published literature on clinical trials with antiadrenergic agents (propranolol, clonidine, guanfacine), selective serotonin reuptake inhibitors (SSRI), other serotonergic agents, monoamine oxidase inhibitors (MAOI), tricyclic antidepressants (TCA), benzodiazepines, anticonvulsants, narcotic… 
Psychopharmacotherapy of posttraumatic stress disorder.
Most clinical studies performed to date to investigate the effectiveness of different psychopharmacological agents in the therapy of PTSD have serious limitations, and comparative studies are needed to determine the usefulness, efficacy, tolerability, and safety of particular psychopharmaceutical drugs in the treatment of this therapeutically and functionally challenging disorder.
A Review of the Psychobiology and Pharmacotherapy of Posttraumatic Stress Disorder
The literature suggests that the stress response triggers certain neuromodulators with subsequent psychoneurological restructuring, and that a comprehensive approach requires multimodel understanding and multimodal treatment.
Complex Trauma and Disorders of Extreme Stress (DESNOS) Diagnosis, Part One: Assessment
Clinicians will learn to understand the progressive developmental impact of traumatic experiences that compromise ongoing psychological, biological, and social maturation and lead to a diagnosis of Complex PTSD or Disorders of Extreme Stress, Not Otherwise Specified (DESNOS).
Managing posttraumatic stress disorder in combat veterans with comorbid traumatic brain injury
Treatment recommendations from VA and Department of Defense’s recently updated VA/DOD Clinical Practice Guideline for Management of Post-Traumatic Stress are considered from the perspective of simultaneously managing comorbid TBI.
Sleep Disordered Breathing in Gulf War Syndrome Veterans and the Effect of Continuous Positive Airway Pressure ( CPAP ) Treatment
  • Psychology, Medicine
  • 2017
Building upon an existing paradigm of neural sensitization, sleep disordered breathing is linked to functional somatic syndromes and anxiety disorders through chronic activation of the hypothalamicpituitary-adrenal axis.
Das Unsagbare darstellen
SummaryTrauma victims are frequently unable to express their horror verbally, but all of a sudden the trauma breaks in vividly and running high and overwhelming feelings such as angst, helplessness, despair, and rage are contained and communicated in a work of art.
Treatment of Civilian and Combat-Related Posttraumatic Stress Disorder with Topiramate
Based on the limited evidence available, topiramate is a possible alternative or adjunct option for patients with PTSD that is refractory to standard treatments.
Overgeneral Memory and Posttraumatic Stress Disorder in Adults Exposed to Family Violence
Childhood exposure to familial violence increases risk for adult pathology, namely posttraumatic stress disorder (PTSD) and depression. Primary PTSD symptoms of hyperarousal and avoidance are


Fluoxetine in posttraumatic stress disorder.
Fluoxetine is an effective pharmacotherapeutic agent for treating PTSD and its associated features, particularly in patients without chronic treatment histories, and non-VA patients responded much better than VA patients.
Biological approaches to the diagnosis and treatment of post-traumatic stress disorder
The neurobiological alterations associated with PTSD may make affected individuals more susceptible to alcohol, opiates, and other illicit drug use, which has important implications for treatment.
Fluoxetine in post-traumatic stress disorder
Fluoxetine was superior for measures of PTSD severity, disability, stress vulnerability, and high end-state function and the placebo-group response was low when viewed as a broad outcome based on a portfolio of ratings, but was higher with a traditional global rating criterion.
The Biological Findings in Post-Traumatic Stress Disorder: A Review1
Suggestive evidence is provided that PTSD is associated with permanent changes in brain mechanisms involving the locus coeruleus, amygdala, and the hypothalamo-pituitary-adrenal axis.
Clonidine in Cambodian Patients with Posttraumatic Stress Disorder
The imipramine-clonidine combination was well tolerated and presents a promising treatment for severely depressed and traumatized patients, although further studies are needed.
Use of thioridazine in post-traumatic stress disorder.
A case involving a 44-year-old combat veteran who experienced severe flashbacks of his time spent in Vietnam is reported, whose symptoms and general state of mind improved significantly while taking the antipsychotic drug thioridazine.
Sertraline in the treatment of rape victims with posttraumatic stress disorder
Posttraumatic stress disorder (PTSD) is a significant problem following rape, yet reports on the efficacy of pharmacological agents in this population are lacking. The results of an open 12-week
Pharmacotherapy for Posttraumatic Stress Disorder Using Phenelzine or Imipramine
By week 5, both medications significantly reduced PTSD symptoms, as assessed by the Impact of Events Scale (IES), but the 44% improvement on phenelzine was greater than the 25% improved on imipramine.
Core symptoms of posttraumatic stress disorder unimproved by alprazolam treatment.
A random-assignment, double-blind crossover trial comparing alprazolam and placebo in posttraumatic stress disorder (PTSD), which found improvement in anxiety symptoms was significantly greater during alpazolam treatment but modest in extent.