Pharmacotherapy for posttraumatic stress disorder: A status report

  title={Pharmacotherapy for posttraumatic stress disorder: A status report},
  author={Matthew J. Friedman},
  journal={Psychiatry and Clinical Neurosciences},
  • M. Friedman
  • Published 1 September 1998
  • Psychology, Biology
  • Psychiatry and Clinical Neurosciences
Pharmacotherapy for posttraumatic stress disorder (PTSD) appears to be a promising approach because many neurobiological systems appear to be altered in PTSD patients. This review encompasses the current published literature on clinical trials with antiadrenergic agents (propranolol, clonidine, guanfacine), selective serotonin reuptake inhibitors (SSRI), other serotonergic agents, monoamine oxidase inhibitors (MAOI), tricyclic antidepressants (TCA), benzodiazepines, anticonvulsants, narcotic… 

A Review of the Psychobiology and Pharmacotherapy of Posttraumatic Stress Disorder

The literature suggests that the stress response triggers certain neuromodulators with subsequent psychoneurological restructuring, and that a comprehensive approach requires multimodel understanding and multimodal treatment.

Treatment of Civilian and Combat-Related Posttraumatic Stress Disorder with Topiramate

Based on the limited evidence available, topiramate is a possible alternative or adjunct option for patients with PTSD that is refractory to standard treatments.

Complex Trauma and Disorders of Extreme Stress (DESNOS) Diagnosis, Part One: Assessment

Clinicians will learn to understand the progressive developmental impact of traumatic experiences that compromise ongoing psychological, biological, and social maturation and lead to a diagnosis of Complex PTSD or Disorders of Extreme Stress, Not Otherwise Specified (DESNOS).

Managing posttraumatic stress disorder in combat veterans with comorbid traumatic brain injury

Treatment recommendations from VA and Department of Defense’s recently updated VA/DOD Clinical Practice Guideline for Management of Post-Traumatic Stress are considered from the perspective of simultaneously managing comorbid TBI.

Overgeneral Memory and Posttraumatic Stress Disorder in Adults Exposed to Family Violence

Childhood exposure to familial violence increases risk for adult pathology, namely posttraumatic stress disorder (PTSD) and depression. Primary PTSD symptoms of hyperarousal and avoidance are

Sleep Disordered Breathing in Gulf War Syndrome Veterans and the Effect of Continuous Positive Airway Pressure ( CPAP ) Treatment

  • Psychology, Medicine
  • 2017
Building upon an existing paradigm of neural sensitization, sleep disordered breathing is linked to functional somatic syndromes and anxiety disorders through chronic activation of the hypothalamicpituitary-adrenal axis.

The psychological impact of motor vehicle accidents

Exposure to a traumatic event may result in the development of Posttraumatic Stress Disorder (PTSD) or Acute Stress Disorder (ASD). Biopsychosocial variables associated with these disorders


The Japanese-language version of the Impact of Event Scale-Revised (IES-R-J) can be a useful self-rating diagnostic instrument particularly for survivors with PTSD symptoms as a clinical concern (PTSD + partial PTSD) and can be used as a validated instrument in future international comparative research.

Das Unsagbare darstellen

SummaryTrauma victims are frequently unable to express their horror verbally, but all of a sudden the trauma breaks in vividly and running high and overwhelming feelings such as angst, helplessness, despair, and rage are contained and communicated in a work of art.



Monoamine Oxidase Inhibitors in Posttraumatic Stress Disorder: Promise and Problems in Indochinese Survivors of Trauma

Evidence is accumulating that the avoidance symptoms of PTSD respond less reliably to chemotherapy and may be less important in characterizing this entity than the intrusive recollection of traumatic events and hyperarousal symptoms.

Biological approaches to the diagnosis and treatment of post-traumatic stress disorder

The neurobiological alterations associated with PTSD may make affected individuals more susceptible to alcohol, opiates, and other illicit drug use, which has important implications for treatment.

Fluoxetine in post-traumatic stress disorder

Fluoxetine was superior for measures of PTSD severity, disability, stress vulnerability, and high end-state function and the placebo-group response was low when viewed as a broad outcome based on a portfolio of ratings, but was higher with a traditional global rating criterion.

The Biological Findings in Post-Traumatic Stress Disorder: A Review1

Suggestive evidence is provided that PTSD is associated with permanent changes in brain mechanisms involving the locus coeruleus, amygdala, and the hypothalamo-pituitary-adrenal axis.

Sertraline treatment of comorbid posttraumatic stress disorder and alcohol dependence.

Sertraline may be useful in the treatment of PTSD complicated by alcoholism, according to a small sample size and the open-label, nonblinded study design.

Open trial of fluvoxamine treatment for combat-related posttraumatic stress disorder.

Fuvoxamine was effective for treating the core intrusion, avoidance, and arousal symptoms of PTSD and the magnitude of change was greater than has been previously reported for antidepressant treatment of male Vietnam combat veterans with PTSD.

Clonidine in Cambodian Patients with Posttraumatic Stress Disorder

The imipramine-clonidine combination was well tolerated and presents a promising treatment for severely depressed and traumatized patients, although further studies are needed.

Use of thioridazine in post-traumatic stress disorder.

A case involving a 44-year-old combat veteran who experienced severe flashbacks of his time spent in Vietnam is reported, whose symptoms and general state of mind improved significantly while taking the antipsychotic drug thioridazine.

Sertraline in the treatment of rape victims with posttraumatic stress disorder

Posttraumatic stress disorder (PTSD) is a significant problem following rape, yet reports on the efficacy of pharmacological agents in this population are lacking. The results of an open 12-week

Pharmacotherapy for Posttraumatic Stress Disorder Using Phenelzine or Imipramine

By week 5, both medications significantly reduced PTSD symptoms, as assessed by the Impact of Events Scale (IES), but the 44% improvement on phenelzine was greater than the 25% improved on imipramine.