Pharmacotherapy for mild hypertension.

@article{Diao2012PharmacotherapyFM,
  title={Pharmacotherapy for mild hypertension.},
  author={Diana Y Diao and James M. Wright and David K Cundiff and François Gueyffier},
  journal={The Cochrane database of systematic reviews},
  year={2012},
  volume={8},
  pages={
          CD006742
        }
}
BACKGROUND People with no previous cardiovascular events or cardiovascular disease represent a primary prevention population. The benefits and harms of treating mild hypertension in primary prevention patients are not known at present. This review examines the existing randomised controlled trial (RCT) evidence. OBJECTIVES PRIMARY OBJECTIVE To quantify the effects of antihypertensive drug therapy on mortality and morbidity in adults with mild hypertension (systolic blood pressure (BP) 140… 

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Pharmacotherapy for mild hypertension.
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Antihypertensive drugs used in the treatment of adults (primary prevention) with mild hypertension (systolic BP 140-159 mmHg and/or diastolic BP 90-99 mmHG) have not been shown to reduce mortality or morbidity in RCTs.
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TLDR
Moderate-quality evidence is provided to show that antihypertensive drugs do not reduce sudden death but do reduce both non-fatal myocardial infarction and fatal myocardia, suggesting that sudden cardiac death may not be caused primarily by acute myocardials.
Effects of blood pressure reduction in mild hypertension: a systematic review and meta-analysis.
TLDR
Blood pressure-lowering therapy is likely to prevent stroke and death in patients with uncomplicated grade 1 hypertension, and withdrawal from treatment due to adverse effects was more common in the active groups.
Drugs for Primary Prevention of Atherosclerotic Cardiovascular Disease: An Overview of Systematic Reviews.
TLDR
This overview demonstrates high-quality evidence to support aspirin, BP-lowering therapy, and statins for primary ASCVD prevention and tobacco cessation drugs for smoking cessation.
Review: In patients with mild hypertension and no CV disease, BP-lowering drugs reduce stroke and mortality
  • M. Tanner
  • Medicine
    Annals of Internal Medicine
  • 2015
TLDR
In patients with mild hypertension and no diagnosed cardiovascular disease, blood pressurelowering drugs (vs placebo or less-intensive regimens) reduce stroke and mortality.
Cochrane review finds no proved benefit in drug treatment for patients with mild hypertension
  • J. Lenzer
  • Medicine
    BMJ : British Medical Journal
  • 2012
TLDR
A Cochrane review of studies conducted in the United Kingdom, Australia, and the United States has found that treating patients with stage 1 (mild) hypertension has no benefit, and patients should throw away their blood pressure pills and focus instead on far more effective as well as evidence based approaches.
Randomized Controlled Trials of Blood Pressure Lowering in Hypertension
TLDR
The results of these meta-analyses provide further support to current hypertension treatment guidelines by showing that BP lowering can significantly reduce major cardiovascular outcomes largely independent of the agents used, significant risk reduction is found at all hypertension grades (stages), and when systolic BP is lowered below a cut off of 140 mm Hg.
Randomized controlled trials of blood pressure lowering in hypertension: a critical reappraisal.
TLDR
The results of these meta-analyses provide further support to current hypertension treatment guidelines by showing that BP lowering can significantly reduce major cardiovascular outcomes largely independent of the agents used, significant risk reduction is found at all hypertension grades (stages).
The Benefits of Detecting and Treating Mild Hypertension: What We Know, and What We Need to Learn
TLDR
The results are consistent with those of prior analyses in hypertension clinical outcome trials that showed that blood pressure reductions, even within this lower range, are associated with favorable cardiovascular outcomes and a recent guideline that recommended relaxing blood pressure goals in patients older than 60 years.
Waste and harm in the treatment of mild hypertension.
  • I. Heath
  • Medicine
    JAMA internal medicine
  • 2013
TLDR
The Cochrane Review concluded that antihypertensive drugs used in the treatment of otherwise healthy adults with mild hypertension have not been shown to reduce mortality or morbidity in randomized clinical trials.
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