Pharmacotherapeutic approaches to treating depression during the perimenopause

  title={Pharmacotherapeutic approaches to treating depression during the perimenopause},
  author={Ricardo P Garay and Thomas Charpeaud and Susan Jane Sinclair Logan and Patrick Hannaert and Raul G Garay and Pierre Michel Llorca and Shefaly Shorey},
  journal={Expert Opinion on Pharmacotherapy},
  pages={1837 - 1845}
ABSTRACT Introduction: Although postnatal depression is now well recognized, there is also a risk of depressive symptoms during perimenopause. The mechanisms underlying perimenopausal depression are still poorly understood; however, there are available treatment options. Areas covered: This review describes: the current pharmacotherapeutic approaches for perimenopausal depression, their strengths and weakness, and provides recommendations on how current treatment can be improved in the future… 

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HRP_220057 215..225

  • 2022



Guidelines for the Evaluation and Treatment of Perimenopausal Depression: Summary and Recommendations.

An expert panel was convened to systematically review the published literature and develop guidelines on the evaluation and management of perimenopausal depression, finding that most midlife women who experience a major depressive episode during the perimenopause have experienced a prior episode of depression.


Methodologic differences of note include menopausal state (perimenopause vs. postmenopause), determination of state (earlier studies used age as a proxy measure), baseline symptomatology (asymptomatic vs. depressive symptoms vs. syndromic depression), route of hormone administration (transdermal vs. oral), and symptom or syndrome measure.

A Multicenter, Randomized, Controlled Trial of Electroacupuncture for Perimenopause Women with Mild-Moderate Depression

EA treatment is effective and safe in relieving depression symptom and improving the quality of life in the perimenopause depression, and the mechanism of this intervention is still unclear.

Assessment of perimenopausal depression: A review.

Depressive Symptoms in the Perimenopause: Prevalence, Assessment, and Guidelines for Treatment

It is found that a positive association may exist between depressive symptoms and the perimenopause, and that a prior history of depression may be associated with such symptoms.

Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.

In women with past PMD that was previously responsive to hormone therapy, the recurrence of depressive symptoms during blinded hormone withdrawal suggests that normal changes in ovarian estradiol secretion can trigger an abnormal behavioral state in these susceptible women.

Investigational drugs in recent clinical trials for treatment-resistant depression

The authors describe the medications for treatment-resistant depression (TRD) in phase II/III of clinical development in the EU and USA and provide an opinion on how current treatment can be improved in the near future.

Depression or menopause? Presentation and management of major depressive disorder in perimenopausal and postmenopausal women.

  • A. ClaytonP. Ninan
  • Medicine, Psychology
    Primary care companion to the Journal of clinical psychiatry
  • 2010
Routine screening of this at-risk population followed by careful assessment for depressive symptoms can help identify the presence of MDD in the menopausal transition.

Estrogen augmentation of antidepressants in perimenopausal depression: a pilot study.

Short-term, low-dose estrogen augmentation of antidepressant medication was significantly associated with improved mood, but not memory, in perimenopausal women with MDD in partial remission.