Pharmacotherapeutic and Non-Pharmacological Options for Refractory and Difficult-to-Treat Seizures

@inproceedings{Mitchell2012PharmacotherapeuticAN,
  title={Pharmacotherapeutic and Non-Pharmacological Options for Refractory and Difficult-to-Treat Seizures},
  author={James W. Mitchell and Stefano Seri and Andrea E. Cavanna},
  booktitle={Journal of central nervous system disease},
  year={2012}
}
It is currently estimated that about 20%-30% of adults and 10%-40% of children diagnosed with epilepsy suffer from uncontrolled or poorly controlled seizures, despite optimal medical management. In addition to its huge economic costs, treatment-refractory epilepsy has a widespread impact on patients' health-related quality of life. The present paper focuses on the concepts of refractory and difficult-to-treat seizures and their pharmacological management. Evidence on efficacy and tolerability… CONTINUE READING

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