Pharmacophore modeling improves virtual screening for novel peroxisome proliferator-activated receptor-gamma ligands

Abstract

Peroxisome proliferator-activated receptor-gamma (PPARγ) is a nuclear hormone receptor involved in regulating various metabolic and immune processes. The PPAR family of receptors possesses a large binding cavity that imparts promiscuity of ligand binding not common to other nuclear receptors. This feature increases the challenge of using computational… (More)
DOI: 10.1007/s10822-015-9831-x

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Cite this paper

@article{Lewis2015PharmacophoreMI, title={Pharmacophore modeling improves virtual screening for novel peroxisome proliferator-activated receptor-gamma ligands}, author={Stephanie N. Lewis and Zulma Garcia and Raquel Hontecillas and Josep Bassaganya-Riera and David R. Bevan}, journal={Journal of computer-aided molecular design}, year={2015}, volume={29 5}, pages={421-39} }