Pharmacophore identification of Raf-1 kinase inhibitors.


A three-dimensional pharmacophore model was developed based on 25 currently available Raf-1 kinase inhibitors. The best pharmacophore hypothesis (Hypo1), consisting of four chemical features (one hydrogen-bond acceptor, one hydrogen-bond donor, and two hydrophobic groups), has a correlation coefficient of 0.972. The results of our study provide a valuable… (More)
DOI: 10.1016/j.bmcl.2008.02.068

Cite this paper

@article{Zhu2008PharmacophoreIO, title={Pharmacophore identification of Raf-1 kinase inhibitors.}, author={Tian Jiao Zhu and Yu Jiao and Ya-Dong Chen and Xuan Wang and Hui-Fang Li and Luyong Zhang and Tao Lu}, journal={Bioorganic & medicinal chemistry letters}, year={2008}, volume={18 7}, pages={2346-50} }