Pharmacophore-based drug design and biological evaluation of novel ABCB1 inhibitors.

Abstract

Overexpression of ABCB1 is one of major barriers for multidrug resistance in chemotherapy and limits drug oral bioavailability. Inhibition of ABCB1 would sensitize multidrug resistance in clinical cancer chemotherapy. With this aim, a 3D pharmacophore model was created based on known ABCB1 inhibitors with correlation coefficient of 0.94, comprising three… (More)
DOI: 10.1111/cbdd.12081

Cite this paper

@article{Zhang2013PharmacophorebasedDD, title={Pharmacophore-based drug design and biological evaluation of novel ABCB1 inhibitors.}, author={Sheng-lie Zhang and Yin-xiang Wei and Qian Li and Hao-Peng Sun and Hui Peng and Qidong You}, journal={Chemical biology & drug design}, year={2013}, volume={81 3}, pages={349-58} }