Pharmacophore-based discovery of triaryl-substituted imidazole as new telomeric G-quadruplex ligand.

Abstract

Discovery of potent and selective ligands for telomeric G-quadruplex DNA is a challenging work. Through a combination approach of pharmacophore model construction, model validation, database virtual screening, chemical synthesis and interaction evaluation, we discovered and confirmed triaryl-substituted imidazole TSIZ01 to be a new telomeric G-quadruplex ligand with potent binding and stabilizing activity to G-quadruplex DNA, as well as a 8.7-fold selectivity towards telomeric G-quadruplex DNA over duplex DNA.

DOI: 10.1016/j.bmcl.2010.12.019

Cite this paper

@article{Chen2011PharmacophorebasedDO, title={Pharmacophore-based discovery of triaryl-substituted imidazole as new telomeric G-quadruplex ligand.}, author={Shuo-Bin Chen and Jia-Heng Tan and Tian-Miao Ou and Shi-Liang Huang and Lin-Kun An and Hai-Bin Luo and Ding Li and Lian-Quan Gu and Zhi-Shu Huang}, journal={Bioorganic & medicinal chemistry letters}, year={2011}, volume={21 3}, pages={1004-9} }