Pharmacophore and docking-based combined in-silico study of KDR inhibitors.


The growth and metastasis of solid tumors is dependent on angiogenesis. The vascular endothelial growth factor (VEGF) and its cell surface receptor in human KDR (kinase domain containing receptor or VEGFR-2) have particular interest because of their importance in angiogenesis. The development of novel inhibitors of VEGFR-2 would be helpful to check the… (More)
DOI: 10.1016/j.jmgm.2009.04.006


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