Pharmacophore Modeling , Atom based 3 D-QSAR and Docking Studies on ADAMTS-5 Inhibitors

@inproceedings{RathiSuganyaPharmacophoreM,
  title={Pharmacophore Modeling , Atom based 3 D-QSAR and Docking Studies on ADAMTS-5 Inhibitors},
  author={P. RathiSuganya and Assistant}
}
  • P. RathiSuganya, Assistant
ADAMTS-5 is an important aggrecanase that cleaves at key sites in the aggrecan core protein, in healthy and diseased cartilage. ADAMTS-5 deficient mice are protected from cartilage erosion in models of experimental arthritis. Therefore inhibition of ADAMTS-5 will be a potential cure for arthritis. In this study pharmacophore model was developed by… CONTINUE READING