Pharmacometric Models for Characterizing the Pharmacokinetics of Orally Inhaled Drugs

@article{Borghardt2015PharmacometricMF,
  title={Pharmacometric Models for Characterizing the Pharmacokinetics of Orally Inhaled Drugs},
  author={Jens Markus Borghardt and Benjamin Kent Weber and Alexander Staab and Charlotte Kloft},
  journal={The AAPS Journal},
  year={2015},
  volume={17},
  pages={853-870}
}
During the last decades, the importance of modeling and simulation in clinical drug development, with the goal to qualitatively and quantitatively assess and understand mechanisms of pharmacokinetic processes, has strongly increased. However, this increase could not equally be observed for orally inhaled drugs. The objectives of this review are to understand the reasons for this gap and to demonstrate the opportunities that mathematical modeling of pharmacokinetics of orally inhaled drugs… CONTINUE READING

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