Pharmacology of the meglitinide analogs: new treatment options for type 2 diabetes mellitus.

@article{Malaisse2003PharmacologyOT,
  title={Pharmacology of the meglitinide analogs: new treatment options for type 2 diabetes mellitus.},
  author={Willy Jean Malaisse},
  journal={Treatments in endocrinology},
  year={2003},
  volume={2 6},
  pages={401-14}
}
The expression meglitinide analogs was introduced in 1995 to cover new molecules proposed as non-sulfonylurea insulinotropic agents and displaying structural analogy with meglitinide, such as repaglinide, nateglinide, and mitiglinide. Meglitinide analogs display, as judged by conformation analysis, a U-shaped configuration similar to that of antihyperglycemic sulfonylureas such as glibenclamide (glyburide) and glimepiride. In rat pancreatic islets incubated in the presence of 7.0 mmol/L D… CONTINUE READING

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