Pharmacology of the isolated heart of the lamprey Lampetra fluviatilis.

@article{Lukomskaya1972PharmacologyOT,
  title={Pharmacology of the isolated heart of the lamprey Lampetra fluviatilis.},
  author={N. J. Lukomskaya and M. J. Michelson},
  journal={Comparative and general pharmacology},
  year={1972},
  volume={3 10},
  pages={
          213-25
        }
}
  • N. J. Lukomskaya, M. J. Michelson
  • Published 1972
  • Chemistry, Medicine
  • Comparative and general pharmacology
  • Abstract 1. 1. Acetylcholine (ACh) 10 −7 increases the rate of beating of the isolated lamprey heart; with higher concentrations a tonotropic effect and a contracture of ventricle muscle are observed. 2. 2. The effect of ACh is reproduced by nicotinomimetics; muscarinomimetics are almost ineefective. Curare-like drugs are potent cholinolytics, but atropine and hexamethonium manifest poor cholinolytic activity. 3. 3. Sebacoyldicholine and suberyldicholine—the bisquaternary compounds having 16… CONTINUE READING
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