Pharmacology of the GABAB receptor in amphibian retina.

  title={Pharmacology of the GABAB receptor in amphibian retina.},
  author={Ning Tian and Malcolm M Slaughter},
  journal={Brain research},
  volume={660 2},
Amacrine and ganglion cells in the amphibian retina contain GABAB, as well as GABAA, receptors. Baclofen, a GABAB agonist, hyperpolarizes the dark membrane potential of these third order neurons and makes their light responses more transient. GABAB receptors in the retina have a similar agonist profile to GABAB receptors described at other sites in the brain. Namely, preferential activation by the R-enantiomer of baclofen, and agonist sensitivity in the order 3-aminopropylphosphinic acid… CONTINUE READING