Corpus ID: 24429004

Pharmacology of secoverine, a new spasmolytic agent with specific antimuscarinic properties. Part 2: General pharmacological properties.

@article{Zwagemakers1980PharmacologyOS,
  title={Pharmacology of secoverine, a new spasmolytic agent with specific antimuscarinic properties. Part 2: General pharmacological properties.},
  author={J. Zwagemakers and V. Claassen},
  journal={Arzneimittel-Forschung},
  year={1980},
  volume={30 9},
  pages={
          1526-34
        }
}
The general pharmacological properties of 1-cyclohexyl-4-[ethyl(p-methoxy-alpha-methylphenethyl)amino]-1-butanone hydrochloride (secoverine hydrochloride), a neurotropic spasmolytic agent with specific antimuscarinic properties, are described. 1. No effects on blood pressure were seen in dogs with doses up to 3 mg/kg .i.v. In hypertensive rats no blood pressure lowering effect was seen after oral doses of 25 and 100 mg/kg. In cats a marginal increase of the blood pressure was observed with i.v… Expand
6 Citations
COMPARISON OF THE AFFINITY OF SECOVERINE FOR SOME MUSCARINIC RECEPTORS
Muscarinic receptor differentiation.