Corpus ID: 36295553

Pharmacology of secoverine, a new spasmolytic agent with specific antimuscarinic properties. Part 1: Antimuscarinic and spasmolytic effects.

@article{Zwagemakers1980PharmacologyOS,
  title={Pharmacology of secoverine, a new spasmolytic agent with specific antimuscarinic properties. Part 1: Antimuscarinic and spasmolytic effects.},
  author={J. Zwagemakers and V. Claassen},
  journal={Arzneimittel-Forschung},
  year={1980},
  volume={30 9},
  pages={
          1517-26
        }
}
1-Cyclohexyl-4-[ethyl(p-methoxy-alpha-methylphenethyl)amino]-1-butanone hydrochloride (secoverine hydrochloride) is a neurotropic spasmolytic agent with specific antimuscarinic properties. On the basis of the results obtained, the possibility exists that secoverine acts only a sub-group of muscarinic receptors. 1. In in vitro experiments the competitive antagonism of secoverine against muscarinomimetics was demonstrated on guinea pig ileum, rat jejunum and calif trachea smooth muscle. On the… Expand
18 Citations
Secoverine selectively antagonizes muscarinic effects in various in vivo preparations.
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