Pharmacology of pyrazolopyridines

  title={Pharmacology of pyrazolopyridines},
  author={J. Patel and J. Malick and A. Salama and M. E. Goldberg},
  journal={Pharmacology Biochemistry and Behavior},
  • J. Patel, J. Malick, +1 author M. E. Goldberg
  • Published 1985
  • Psychology, Medicine
  • Pharmacology Biochemistry and Behavior
  • Pyrazolopyridines (PZP's) in general represent a chemically unique class of non-sedative anxiolytic agents. Tracazolate (ICI 136,753) is a member of pyrazolopyridine series that has shown anxiolytic properties in animal models. Tracazolate demonstrates a wider separation between sedative and therapeutic doses than do benzodiazepines. In addition, tracazolate appears to cause fewer adverse interactions than the benzodiazepines in combination with barbiturates and alcohol. In interaction studies… CONTINUE READING
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