Pharmacology of pyrazolopyridines

@article{Patel1985PharmacologyOP,
  title={Pharmacology of pyrazolopyridines},
  author={Jitendra B. Patel and Jeffrey B. Malick and Andre I. Salama and Morton E. Goldberg},
  journal={Pharmacology Biochemistry and Behavior},
  year={1985},
  volume={23},
  pages={675-680}
}
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36 Citations
Background Citations
5
Results Citations
1

36 Citations

Enhancement of GABAergic transmission by zolpidem, an imidazopyridine with preferential affinity for type I benzodiazepine receptors.
INVESTIGATION OF SEIZURE ACTIVITY AFTER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITION WITH SECOND MESSENGER AND CALCIUM ION CHANNEL INHIBITION IN MICE
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The study reveals that identification of new cAMP mediated phosphodiesterases family members offers a potential new therapy for epilepsy management in future and confirms that both CCM and CCB possess anti- convulsant activity.
Tracazolate Reveals a Novel Type of Allosteric Interaction with Recombinant γ-Aminobutyric AcidA Receptors
TLDR
The first detailed pharmacological study examining the effects of tracazolate on a range of recombinant GABA(A) receptors expressed in Xenopus laevis oocytes found its intrinsic efficacy, potentiation, or inhibition is determined by the nature of the third subunit (gamma1-3, delta, or epsilon) within the receptor complex.
Structure, pharmacology, and function of GABAA receptor subtypes.
Effect of psychotomimetics and some putative anxiolytics on stress-induced hyperthermia
TLDR
Stress-induced hyperthermia (SIH), which is seen in the last mice removed from the cage, is a novel animal model sensitive to anxiolytic drugs and MK-801 (0.5–1 mg/kg, os), PCP, PCP and d-amphetamine evokedhyperthermia in the first set of mice and prevented a further stress-induced rise of body temperature in theLast set of mouse.
Yohimbine‐induced seizures in mice: A model predictive of potential anxiolytic and GABA‐mimetic agents
TLDR
Since yohimbine has been reported to be anxiogenic in animals and man, this assay may be relevant for the prediction of anxiolytic agents, and compounds active in this test have shown anxIOlytic activity in behavioral conflict paradigms.
Etazolate, a neuroprotective drug linking GABAA receptor pharmacology to amyloid precursor protein processing
TLDR
Etazolate dose‐dependently protected rat cortical neurons against Aβ‐induced toxicity and indicated a relationship between GABAA receptor signalling, the α‐secretase pathway and neuroprotection, documenting a new therapeutic approach for AD treatment.
Synthesis and antibacterial activity of some novel pyrazolopyridine derivatives
Eight pyrazolo[3,4-b]pyridine derivatives have been synthesized by Friedländer condensation of 5-aminopyrazole-4-carbaldehyde with active methylene compounds in basic medium. These compounds have…
Characterisation of the discriminative stimulus properties of flumazenil.
Deciphering the robustness of pyrazolo-pyridine carboxylate core structure-based compounds for inhibiting α-synuclein in transgenic C. elegans model of Synucleinopathy.
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