Pharmacology of protoporphyrin IX in nude mice after application of ALA and ALA esters.

@article{Moan2003PharmacologyOP,
  title={Pharmacology of protoporphyrin IX in nude mice after application of ALA and ALA esters.},
  author={Johan E. Moan and Li-wei Ma and Asta Juzeniene and Vladimir Iani and Petras Juzenas and Fabio Apricena and Qian Peng},
  journal={International journal of cancer},
  year={2003},
  volume={103 1},
  pages={132-5}
}
Aminolevulinic acid (ALA), ALA methylester (ALA-Me) and ALA hexylester (ALA-Hex) were topically applied for 5 and 20 hr, respectively, on normal skin of mice. The distribution of protoporphyrin IX (PpIX) induced in 7 different tissues by these drugs was determined either by spectrofluorometric measurements with an optical fibre probe or by chemical extraction of PpIX from the tissues. The results from these 2 types of measurements were compared. Both methods showed that ALA and the esters… CONTINUE READING