Pharmacology of procaine in the horse: procaine esterase properties of equine plasma and synovial fluid.

@article{Tobin1976PharmacologyOP,
  title={Pharmacology of procaine in the horse: procaine esterase properties of equine plasma and synovial fluid.},
  author={Thomas S. Tobin and Jacqueline A. Blake and L Sturma and Samuel E. Arnett},
  journal={American journal of veterinary research},
  year={1976},
  volume={37 10},
  pages={
          1165-70
        }
}
Procaine added to whole equine blood or diluted plasma was hydrolyzed with half times of approximately 9 and 12 minutes, respectively, at 37 C. This hydrolytic activity was sensitive to heating and physostigmine, but did not affect procainamide. At pharmacologic concentrations of procaine, the rate of the hydrolytic reaction depended directly on the concentrations of plasma or procaine in the system and was less in whole blood than in plasma. These properties are consistent with hydrolysis… CONTINUE READING