Pharmacology of potent and selective S2-serotonergic antagonists.

  title={Pharmacology of potent and selective S2-serotonergic antagonists.},
  author={Paul A. J. Janssen},
  journal={Journal of cardiovascular pharmacology},
  volume={7 Suppl 7},
Ketanserin is the prototype of a new series of serotonergic antagonists that competitively and selectively block 5-hydroxytryptamine (S2) serotonergic receptors. Ketanserin and its analogues antagonize the events mediated by this receptor, i.e., serotonin-induced vasoconstriction, bronchoconstriction, and platelet aggregation, irrespective of whether serotonin acts directly or amplifies the effect of vasoconstrictors or platelet aggregating agents. The antagonism is pure because compounds such… CONTINUE READING

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