Pharmacology of phosphodiesterase-5 inhibitors.

  title={Pharmacology of phosphodiesterase-5 inhibitors.},
  author={Jackie D. Corbin and Sharron H. Francis},
  journal={International journal of clinical practice},
  volume={56 6},
The clinical properties (efficacy and safety profile) of a medicine are related not only to its mode of action, but also to its selectivity for its target (usually a receptor or enzyme) and are also influenced by its pharmacokinetic properties (absorption, distribution, metabolism and elimination). The growing number of phosphodiesterase inhibitors that are selective for phosphodiesterase-5 (PDE5) represent a promising new class of compounds that are useful for the treatment of erectile… CONTINUE READING


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