Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders

  title={Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders},
  author={Sarah K. Leonard and Jason M. Dwyer and Stacey J. Sukoff Rizzo and Brian J. Platt and Sheree F. Logue and Sarah J. Neal and Jessica E. Malberg and Chad E. Beyer and Lee E. Schechter and Sharon J Rosenzweig-Lipson and Robert H Ring},
Neuropeptide S (NPS) and its receptor (NPSR) comprise a recently deorphaned G protein-coupled receptor system. Recent reports implicate NPS in the mediation of anxiolytic-like activity in rodents. To extend the characterization of NPS, the present studies examined the in vitro pharmacology of mouse NPSR and the in vivo pharmacology of NPS in three preclinical mouse models predictive of anxiolytic action: the four-plate test (FPT), elevated zero maze (EZM), and stress-induced hyperthermia (SIH… CONTINUE READING


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