Pharmacology of methylphenidate, amphetamine enantiomers and pemoline in attention‐deficit hyperactivity disorder

@article{Patrick1997PharmacologyOM,
  title={Pharmacology of methylphenidate, amphetamine enantiomers and pemoline in attention‐deficit hyperactivity disorder},
  author={Kennerly Sexton Patrick and John Seth Markowitz},
  journal={Human Psychopharmacology: Clinical and Experimental},
  year={1997},
  volume={12}
}
  • K. Patrick, J. Markowitz
  • Published 1 November 1997
  • Biology, Chemistry
  • Human Psychopharmacology: Clinical and Experimental
Racemic methylphenidate remains the drug of choice for attention‐deficit hyperactivity disorder (ADHD). Methylphenidate appears to produce psychostimulation by inhibiting the presynaptic uptake of impulse‐released dopamine. The absolute bioavailability of methylphenidate in humans is quite low and variable: mean 23 per cent for the therapeutic (+)‐isomer and 5 per cent for the (−)‐isomer. The primary site of presystemic metabolism may be the gut and/or intestinal wall. Brain concentrations of… 

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