Pharmacology of lorcainide.

  title={Pharmacology of lorcainide.},
  author={D. Keefe},
  journal={The American journal of cardiology},
  volume={54 4},
  • D. Keefe
  • Published 1984
  • Medicine
  • The American journal of cardiology
  • Lorcainide is a new type 1 antiarrhythmic drug that is well absorbed orally, with bioavailability increasing with both dose and continued administration. It is metabolized through the liver, and patients with significant liver disease will require dosage reduction. The drug has an active metabolite, norlorcainide, whose activity is similar to that of lorcainide but whose half-life is 26 hours instead of 8 for the parent compound. The levels of this metabolite are nearly twice those of… CONTINUE READING
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