Pharmacology of conjugated equine estrogens: Efficacy, safety and mechanism of action

@article{Bhavnani2014PharmacologyOC,
  title={Pharmacology of conjugated equine estrogens: Efficacy, safety and mechanism of action},
  author={Bhagu R. Bhavnani and Frank Z. Stanczyk},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2014},
  volume={142},
  pages={16-29}
}
  • B. Bhavnani, F. Stanczyk
  • Published 2014
  • Medicine, Chemistry
  • The Journal of Steroid Biochemistry and Molecular Biology
Oral conjugated equine estrogens (CEE) are the most used estrogen formulation for postmenopausal hormone therapy either alone or in combination with a progestin. CEE is most commonly used for the management of early menopausal symptoms such as hot flashes, vaginitis, insomnia, and mood disturbances. Additionally, if used at the start of the menopausal phase (age 50-59 years), CEE prevents osteoporosis and may in some women reduce the risk of cardiovascular disease (CVD) and Alzheimer's disease… Expand
Hepatic steroid sulfatase critically determines estrogenic activities of conjugated equine estrogens in human cells in vitro and in mice
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TLDR
Equilin blocks L‐type Ca2+ channels less effectively than 17&bgr;‐estradiol, and equally relaxes resistance mesenteric arteries by blockingCa2+ entry on smooth muscle. Expand
Marketplace Analysis of Conjugated Estrogens: Determining the Consistently Present Steroidal Content with LC-MS
TLDR
The aim of the current study is to develop a LC method that can reliably detect multiple steroidal components in conjugated estrogen tablets and measure their relative amount. Expand
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