Pharmacology of antidepressants: selectivity or multiplicity?

  title={Pharmacology of antidepressants: selectivity or multiplicity?},
  author={Herman G. M. Westenberg},
  journal={The Journal of clinical psychiatry},
  volume={60 Suppl 17},
  pages={4-8; discussion 46-8}
The understanding of mechanisms of antidepressant action has evolved over time. The strong antidepressant activity of the tricyclic antidepressants (TCAs) has supported the role of both norepinephrine and serotonin (5-HT) in depression and the mechanism involved in antidepressant action. The next generation of antidepressants included the selective serotonin reuptake inhibitors (SSRIs), further supporting the role of serotonin, while the selective norepinephrine reuptake inhibitors such as… CONTINUE READING
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