Pharmacology of amineptine, an antidepressant agent acting on the dopaminergic system: a review.

@article{Garattini1997PharmacologyOA,
  title={Pharmacology of amineptine, an antidepressant agent acting on the dopaminergic system: a review.},
  author={Silvio Garattini},
  journal={International clinical psychopharmacology},
  year={1997},
  volume={12 Suppl 3},
  pages={
          S15-9
        }
}
Amineptine is a tricyclic antidepressant agent with a unique capacity to reduce dopamine uptake selectively in vitro: this effect is also obtained in vivo. In vivo, amineptine increases striatal homovanillic acid without affecting the levels of other metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and 3-methoxytyramine. However, relatively high doses of amineptine preferentially lower the extracellular DOPAC level, assessed by pulse voltammetry, in the nucleus accumbens but not in the… CONTINUE READING

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