Pharmacology of adriamycin: the message to the clinician.

  title={Pharmacology of adriamycin: the message to the clinician.},
  author={Jeffrey Cummings and John F. Smyth},
  journal={European journal of cancer & clinical oncology},
  volume={24 4},
In attempting to describe the human pharmacology of ADR, one is aware of the gaps in our knowledge and shortcomings of the available data. Nevertheless, such information is essential if we are ever to be able to convert rationally in vitro observations into clinical pharmacologic effect or, as is more often the case, explain why the desired effect has not been produced. Clinical pharmacokinetic studies to-date suggest that there is a clear relationship between ADR blood levels and toxicity. No… CONTINUE READING

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