Pharmacology of adapalene

@article{Michell1998PharmacologyOA,
  title={Pharmacology of adapalene},
  author={Michell and Jomard and D{\'e}marchez},
  journal={British Journal of Dermatology},
  year={1998},
  volume={139}
}
Adapalene, a synthetic retinoid, is a new drug proposed for the treatment of acne patients. Studies on the in vitro and in vivo pharmacology of adapalene have shown that it is very active on cell and tissue proliferation and differentiation. Furthermore, adapalene has anti‐inflammatory potential as determined by its anti‐AP1 activity. Adapalene interacts selectively with the nuclear receptors RARβ and RARγ, and its activity on proliferation and differentiation can be blocked by a RAR… Expand
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97 Citations

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References

SHOWING 1-10 OF 25 REFERENCES
Efficacy and safety comparison of adapalene (CD271) gel and tretinoin gel in the topical treatment of acne vulgaris. A European multicentre trial
  • 23
Retinoic acid improves epidermal morphogenesis.
  • 208
Selective synthetic ligands for human nuclear retinoic acid receptors.
  • 71
9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα
  • 1,106
Determination of retinoid activity by an enzyme-linked immunosorbent assay.
  • 24
Differentiation of F9 embryonal carcinoma cells by synthetic retinoids: amplitude of plasminogen activator production does not depend on retinoid potency or affinity for F9 nuclear retinoic acid receptors.
  • 14
Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.
  • 1,096
  • PDF
Retinoic acid-induced modifications in the growth and cell surface components of a human carcinoma (HeLa) cell line.
  • 62
A decade of molecular biology of retinoic acid receptors
  • P. Chambon
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1996
  • 2,822
A human retinoic acid receptor which belongs to the family of nuclear receptors
  • 1,951
...
1
2
3
...