Pharmacology of adapalene

@article{Michell1998PharmacologyOA,
  title={Pharmacology of adapalene},
  author={Michell and Jomard and D{\'e}marchez},
  journal={British Journal of Dermatology},
  year={1998},
  volume={139}
}
Adapalene, a synthetic retinoid, is a new drug proposed for the treatment of acne patients. Studies on the in vitro and in vivo pharmacology of adapalene have shown that it is very active on cell and tissue proliferation and differentiation. Furthermore, adapalene has anti‐inflammatory potential as determined by its anti‐AP1 activity. Adapalene interacts selectively with the nuclear receptors RARβ and RARγ, and its activity on proliferation and differentiation can be blocked by a RAR… Expand
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