Pharmacology of adapalene

@article{Michell1998PharmacologyOA,
  title={Pharmacology of adapalene},
  author={Michell and Jomard and D{\'e}marchez},
  journal={British Journal of Dermatology},
  year={1998},
  volume={139}
}
Adapalene, a synthetic retinoid, is a new drug proposed for the treatment of acne patients. Studies on the in vitro and in vivo pharmacology of adapalene have shown that it is very active on cell and tissue proliferation and differentiation. Furthermore, adapalene has anti‐inflammatory potential as determined by its anti‐AP1 activity. Adapalene interacts selectively with the nuclear receptors RARβ and RARγ, and its activity on proliferation and differentiation can be blocked by a RAR… 
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Adapalene biochemistry and the evolution of a new topical retinoid for treatment of acne
TLDR
The history of the development of adapalene, its unique physical and biochemical properties, and the pharmacological studies that demonstrate a wide range of retinoid‐receptor, genetic and anti‐inflammatory effects are reviewed, all of which contribute to the therapeutic efficacy and improved tolerability of adAPalene observed in the clinical use of this agent for the treatment of acne.
A Review on a Third Generation Retinoidal Agent: Adapalene
TLDR
The present work reviews the biological and pharmaceutical profile of Adapalene and suggests that it may be an important target for pharmaceutical industries.
Recent advances in the use of adapalene 0.1%/benzoyl peroxide 2.5% to treat patients with moderate to severe acne
  • J. Leyden
  • Medicine, Biology
    The Journal of dermatological treatment
  • 2016
Abstract The central role of inflammation in acne is now more clearly understood. Adapalene, a third-generation topical retinoid, down-regulates toll-like receptor 2 expression and inhibits activator…
Retinoid Therapy for Acne
  • M. Chivot
  • Medicine
    American journal of clinical dermatology
  • 2005
TLDR
It is preferable not to use them in topical form for pregnant women, although a pregnancy test is only compulsory for tazarotene, and Precautions must be taken for women of childbearing age due to its teratogenicity.
In vitro modulation of TLR‐2, CD1d and IL‐10 by adapalene on normal human skin and acne inflammatory lesions
Abstract  The anti‐inflammatory mechanisms of adapalene, a synthetic retinoid used for the treatment of acne patients, are partially understood. They seem particularly related to the modulation of…
The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro
TLDR
The results clearly indicate the superiority of ADA compared to CRA and suggest that ADA may be far more suitable as an adjunctive therapeutic agent for treatment of colon cancer in vivo.
Adapalene 0.1% and benzoyl peroxide 2.5% combination gel for the treatment of acne vulgaris
TLDR
Results from clinical trials provide robust evidence that this fixed-dose combination gel is significantly more efficacious than its corresponding monotherapies and has a mild tolerability profile similar to that of adapalene alone.
A comparative trial of two retinoids commonly used in the treatment of acne vulgaris
TLDR
Both drugs have similar efficacy in the resolution of acne lesions but tretinoin gel microsphere may result in a faster onset of action in the reduction of comedones compared to adapalene.
The Effects of Topical Application of Adapalene and Tretinoin on Tissue Hydroxyproline Content in Wound Model Impaired by Corticosteroid
TLDR
It is demonstrated that methyl prednisolon acetate significantly decreases the tissue hydroxyproline content of full-thickness wound in rats and topical application of adapalene and tretinoin appreciably reverses this inhibitory effect of corticosteroid.
Transdermal Penetration of Topical Drugs Used in the Treatment of Acne
TLDR
Topical anti-acne agents are well tolerated and, as would be expected from their limited transdermal uptake, other significant safety concerns have not so far arisen.
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