Pharmacology of a novel selective 5-hydroxytryptamine1B receptor antagonist, AR-A000002

@article{Stenfors2004PharmacologyOA,
  title={Pharmacology of a novel selective 5-hydroxytryptamine1B receptor antagonist, AR-A000002},
  author={Carina Stenfors and Teresa Hallerb{\"a}ck and Lars-Gunnar Larsson and Carin Wallsten and Svante B. Ross},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={369},
  pages={330-337}
}
The terminal 5-HT1B autoreceptors have attracted great pharmacological interest since they are potential targets for compounds modifying serotonergic neurotransmission. In the present work the in vivo biochemical properties of AR-A000002 ((R)-N-[5-methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-morpholinobenzamide), a novel selective 5-HT1B receptor antagonist, are reported.The effects of AR-A000002 on: 5-HT metabolism was measured as the ratio between 5-HIAA and 5-HT… 

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Repeated administration of the 5-HT1B receptor antagonist SB-224289 blocks the desensitisation of 5-HT1B autoreceptors induced by fluoxetine in rat frontal cortex

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High-resolution imaging of brain 5-HT 1B receptors in the rhesus monkey using [11C]P943.

Involvement of the 5-HT1A and the 5-HT1B receptor in the regulation of sleep and waking

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