Pharmacology of Modulators of Alternative Splicing

  title={Pharmacology of Modulators of Alternative Splicing},
  author={David O. Bates and Jonathan C. Morris and Sebastian Oltean and Lucy F. Donaldson},
  journal={Pharmacological Reviews},
  pages={63 - 79}
More than 95% of genes in the human genome are alternatively spliced to form multiple transcripts, often encoding proteins with differing or opposing function. The control of alternative splicing is now being elucidated, and with this comes the opportunity to develop modulators of alternative splicing that can control cellular function. A number of approaches have been taken to develop compounds that can experimentally, and sometimes clinically, affect splicing control, resulting in potential… 

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