Pharmacology of LY201409, a Potent Benzamide Anticonvulsant

@article{Robertson1988PharmacologyOL,
  title={Pharmacology of LY201409, a Potent Benzamide Anticonvulsant},
  author={David Wayne Robertson and Ronald R. Lawson and Robert C. Rathbun and J. David Leander},
  journal={Epilepsia},
  year={1988},
  volume={29}
}
Summary: LY201116 [4‐amino‐N‐(2,6‐dimethylphe‐nyl)benzamide], an effective anticonvulsant in several animal models, is rapidly metabolized by JV‐acetylation in rats, mice and monkeys. In an attempt to preclude metabolic Af‐acetylation sterically, we investigated LY201409, an analogue possessing two methyl groups or‐tho to the 4‐amino substituent. This structural modification successfully altered the metabolic pathway, and LY201409 displayed potent anticonvulsant activity. LY201409 antagonized… 
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