Pharmacology of GPR55 in Yeast and Identification of GSK494581A as a Mixed-Activity Glycine Transporter Subtype 1 Inhibitor and GPR55 Agonist

@article{Brown2011PharmacologyOG,
  title={Pharmacology of GPR55 in Yeast and Identification of GSK494581A as a Mixed-Activity Glycine Transporter Subtype 1 Inhibitor and GPR55 Agonist},
  author={A. Brown and D. Daniels and Mumta Kassim and S. Brown and Carl P. Haslam and Victoria R. Terrell and J. Brown and P. Nichols and P. C. Staton and A. Wise and S. Dowell},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2011},
  volume={337},
  pages={236 - 246}
}
  • A. Brown, D. Daniels, +8 authors S. Dowell
  • Published 2011
  • Biology, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • GPR55 is a G protein-coupled receptor activated by l-α-lysophosphatidylinositol and suggested to have roles in pain signaling, bone morphogenesis, and possibly in vascular endothelial cells. It has affinity for certain cannabinoids (molecules that interact with the cannabinoid CB1 and CB2 receptors), but investigation of its functional role in cell-based systems and in tissue has been limited by a lack of selective pharmacological tools. Here, we present our characterization of GPR55 in the… CONTINUE READING
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    References

    SHOWING 1-10 OF 43 REFERENCES
    Pharmacological characterization of GPR55, a putative cannabinoid receptor.
    • 183
    • Highly Influential
    The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids*
    • 1,427
    • PDF
    Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay
    • 266
    • PDF
    Atypical Responsiveness of the Orphan Receptor GPR55 to Cannabinoid Ligands*
    • 231
    • Highly Influential
    • PDF
    The enigmatic pharmacology of GPR55.
    • R. Ross
    • Biology, Medicine
    • Trends in pharmacological sciences
    • 2009
    • 250
    The GPR55 ligand L‐α‐lysophosphatidylinositol promotes RhoA‐dependent Ca2+ signaling and NFAT activation
    • 236
    • Highly Influential
    2-Arachidonoyl-sn-glycero-3-phosphoinositol: a possible natural ligand for GPR55.
    • 155
    GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current
    • 493
    • Highly Influential
    • PDF
    Is GPR55 an anandamide receptor?
    • 28
    Novel cannabinoid receptors
    • A. J. Brown
    • Biology, Medicine
    • British journal of pharmacology
    • 2007
    • 348
    • Highly Influential