Pharmacology of GPR55 in Yeast and Identification of GSK494581A as a Mixed-Activity Glycine Transporter Subtype 1 Inhibitor and GPR55 Agonist

  title={Pharmacology of GPR55 in Yeast and Identification of GSK494581A as a Mixed-Activity Glycine Transporter Subtype 1 Inhibitor and GPR55 Agonist},
  author={A. Brown and D. Daniels and Mumta Kassim and S. Brown and Carl P. Haslam and Victoria R. Terrell and J. Brown and P. Nichols and P. C. Staton and A. Wise and S. Dowell},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={236 - 246}
  • A. Brown, D. Daniels, +8 authors S. Dowell
  • Published 2011
  • Biology, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • GPR55 is a G protein-coupled receptor activated by l-α-lysophosphatidylinositol and suggested to have roles in pain signaling, bone morphogenesis, and possibly in vascular endothelial cells. It has affinity for certain cannabinoids (molecules that interact with the cannabinoid CB1 and CB2 receptors), but investigation of its functional role in cell-based systems and in tissue has been limited by a lack of selective pharmacological tools. Here, we present our characterization of GPR55 in the… CONTINUE READING
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