Pharmacology of GABA receptor CI− channels in rat retinal bipolar cells

  title={Pharmacology of GABA receptor CI− channels in rat retinal bipolar cells},
  author={Andreas Feigenspan and Heinz Wässle and Joachim Bormann},
γ-AMlNOBUTYRlC acid (GABA), a major inhibitory neurotransmitter in the mammalian nervous system, is known to operate bicuculline-sensitive CI− channels through GABAA receptors and bicuculline-insensitive cation channels through GABAB receptors1,2. Recent observations indicate that the retina may contain GABA receptors with unusual pharmacological properties3–5. Here we report that GABA gates bicuculline-insensitive CI− channels in rod bipolar cells of the rat retina, which were not modulated by… 

GABA-gated Cl− Channels in the rat retina

GABAC receptors on ferret retinal bipolar cells: A diversity of subtypes in mammals?

The results suggest that there may be a diversity of GABAc receptor subtypes on mammalian bipolar cells, and that GABAC receptors on ferret bipolar cells resemble those in lower vertebrates rather than those in the rat retina.

Different contributions of GABAA and GABAC receptors to rod and cone bipolar cells in a rat retinal slice preparation.

A functional role for the modulation of GABAC receptors by the metabotropic glutamate receptors mGluR1/5 is suggested, supporting the hypothesis of distinct functional roles for the different types of cone bipolar cells.

A novel GABA receptor on bipolar cell terminals in the tiger salamander retina

GA receptors on bipolar terminals appear to be pharmacologically different from the GABA receptors found on ganglion cell dendrites, which is similar to the pharmacology reported for the rho 1 GABA receptor subunit that was isolated from retina and expressed in Xenopus oocytes.

Contributions of GABAA receptors and GABAC receptors to acetylcholine release and directional selectivity in the rabbit retina

The results with SR-95531 and bicuculline indicate that GABAA receptors mediate the inhibition responsible for directional selectivity, and suggests that feedforward GAB AA inhibition, as opposed to feedback at bipolar terminals, is responsible for the null inhibition underlying directionalSelectivity.



gamma-Aminobutyric acid receptor channels in adrenal chromaffin cells: a patch-clamp study.

  • J. BormannD. Clapham
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1985
GABA-induced currents are potentiated by diazepam, indicating that anxiolytic drugs like the benzodiazepines might be involved in the regulation of anxiety states in the peripheral nervous system.

Expression of mammalian gamma-aminobutyric acid receptors with distinct pharmacology in Xenopus oocytes.

Compared the electrical and pharmacological properties of GABA receptors expressed by poly(A)+ RNA isolated from mammalian brain and retina, these results suggest that mammalian retina contains RNAs encoding GABA receptors with distinct pharmacology.

Patch-clamp study of gamma-aminobutyric acid receptor Cl- channels in cultured astrocytes.

  • J. BormannH. Kettenmann
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1988
In neurons and chromaffin cells, methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate reduces the sensitivity of the GABA receptor, indicating that neuronal and glial GABA/benzodiazepine receptor--Cl- channel complexes are different.

Properties of GABA-activated whole-cell currents in bipolar cells of the rat retina.

The observation that bipolar cells in the rat retina are relatively homogeneous in terms of their sensitivity to GABA and glycine lead us to postulate that the functional significance of the presence of receptors and their distribution on a neuron may be dictated more by the topography of the presynaptic inputs than by its inherent chemosensitivity.

GABA-activated single channel currents in outside-out membrane patches from rat retinal ganglion cells

Evidence suggests that GABA acts directly on the retinal ganglion cells as an inhibitory transmitter as it does elsewhere in the mammalian central nervous system.

Effects of glycine and GABA on isolated bipolar cells of the mouse retina.

Glycine and GABA, both putative neurotransmitters of amacrine cells, mediate inhibition of bipolar cells in the mouse retina and are suggested to work on separate receptor molecules.

Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.

  • G. CuttingL. Lu G. Uhl
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1991
Features are consistent with the identification of a GABA subunit, GABA rho 1, with prominent retinal expression that increases the diversity and tissue specificity of this ligand-gated ion-channel receptor family.