Pharmacology of Combined α-β-Blockade I

@article{Louis2012PharmacologyOC,
  title={Pharmacology of Combined $\alpha$-$\beta$-Blockade I},
  author={William John Louis and John J. McNeil and Olaf H. Drummer},
  journal={Drugs},
  year={2012},
  volume={28},
  pages={16-34}
}
SumarySeveral compounds of the chemical class arylethanolamines have been shown to possess combined α- or vasodilator and β-adrenoceptor blocking properties. The first drug was labetalol (AH5158)[5-(1-hydroxy-2)1-methyl-3-phenylpropyl(amino)-ethyl(salicylamide)]. Others include medroxalol, bucindolol and YM-09538, which differ from labetalol either by the nature of the substitution on the primary benzene ring and/or on the terminal nitrogen. All of these drugs are non-selective β-blockers… 
14 Citations

Combined α- and β-Receptor Inhibition in the Treatment of Hypertension

The combination of α- with β-adrenoceptor blockade represents a useful addition to the drugs available for the treatment of hypertension, and labetalol is used in all grades of hypertension alone or in combination with other antihypertensives when required.

Progress in Antihypertensive Therapy with a Multiple-Action Drug

The mode of antihypertensive action of β-blockade remains unclear, as does the exact contribution of the 3 mechanisms of peripheral vasodilatation, but the combination of pharmacological effects represents an additional means of lowering blood pressure.

Antihypertensive treatment with beta-blockers in the metabolic syndrome: a review.

Vasodilating action of Carvedilol and Nebivolol, due respectively to alpha1-blocking effect and release of nitric oxide, explains the lack of adverse metabolic effects of these beta-blockers that could also be used in hypertensive patients with metabolic syndrome.

Pharmacological management of hypertensive emergencies and urgencies: focus on newer agents

Clevidipine, a third-generation dihydropyridine calcium-channel blocker with unique pharmacodynamic and pharmacokinetic properties was added to the therapeutic armamentarium and was shown in clinical trials to reduce mortality when compared with nitroprusside.

Heart rate control with adrenergic blockade: Clinical outcomes in cardiovascular medicine

Clinical evidence suggests that attainment of HR control is an important treatment objective for patients with cardiovascular conditions, and vasodilating β-blocker efficacy may aid in accomplishing improved outcomes.

Impact of intravenous infusion of labetalol combined with magnesium sulfate versus hydralazine combined with magnesium sulfate on fetomaternal hemodynamics in severe preeclampsia

Both labetalol and hydralazine intravenous infusion regimens are well tolerated and effective in controlling severe hypertension in pregnant women with severe preeclampsia in combination with magnesium sulfate.

Treatment of Acute Severe Hypertension

Patients with hypertensive emergencies are best treated in an intensive care unit with titratable, intravenous, hypotensive agents, including labetalol, esmolol, fenoldopam, nicardipine and sodium nitroprusside.

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