• Corpus ID: 27158296

Pharmacology of BMY 20064, a potent Ca2+ entry blocker and selective alpha 1-adrenoceptor antagonist.

@article{Stanton1988PharmacologyOB,
  title={Pharmacology of BMY 20064, a potent Ca2+ entry blocker and selective alpha 1-adrenoceptor antagonist.},
  author={H. C. Stanton and L. Rosenberger and R. Hanson and J. Fleming and G. Poindexter},
  journal={Journal of cardiovascular pharmacology},
  year={1988},
  volume={11 4},
  pages={
          387-95
        }
}
BMY 20064 is a dihydropyridine Ca2+ entry blocker with potent and selective alpha 1-adrenoceptor antagonist properties. The drug was equal in potency to nifedipine as a Ca2+ entry blocker in depolarized smooth muscle preparations. It was less active than nifedipine in antagonizing Ca2+-induced contractions of isolated guinea pig papillary muscles paced at 0.2, 1.0, or 2 Hz. BMY 20064 was a potent (0.1-0.2 X prazosin) and selective alpha 1-adrenoceptor antagonist in radioligand binding assays…