Pharmacology and safety of glycerol phenylbutyrate in healthy adults and adults with cirrhosis.

@article{Mcguire2010PharmacologyAS,
  title={Pharmacology and safety of glycerol phenylbutyrate in healthy adults and adults with cirrhosis.},
  author={Brendan M. Mcguire and Igor A. Zupanets and Mark E. Lowe and Xunjun Xiao and V. Syplyviy and Jon P R Monteleone and Sharron Gargosky and Klara Dickinson and Antonia Tercero Mart{\'i}nez and Masoud Mokhtarani and Bruce F. Scharschmidt},
  journal={Hepatology},
  year={2010},
  volume={51 6},
  pages={
          2077-85
        }
}
UNLABELLED Phenylbutyric acid (PBA), which is approved for treatment of urea cycle disorders (UCDs) as sodium phenylbutyrate (NaPBA), mediates waste nitrogen excretion via combination of PBA-derived phenylacetic acid with glutamine to form phenylactylglutamine (PAGN) that is excreted in urine. Glycerol phenylbutyrate (GPB), a liquid triglyceride pro-drug of PBA, containing no sodium and having favorable palatability, is being studied for treatment of hepatic encephalopathy (HE). In vitro and… CONTINUE READING

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